The LUMINATE project embarks on a journey to redefine osteochondral (OC) tissue regeneration, ensuring that patients suffering from knee cartilage and bone injuries receive groundbreaking, personalized treatment. Through its innovative in situ bioprinting technology, LUMINATE develops a minimally invasive, one-stage solution that could eliminate the need for traditional joint replacement surgeries. Each work package (WP) plays a crucial role in shaping this future, combining cutting-edge bioprinting, biomaterial engineering, artificial intelligence, and clinical validation to bring EndoFLight—the project’s revolutionary bioprinting suite—into reality.